Publications
Leadscope has written numerous articles and presented at international conference in addition to being included in several reviews and articles. Please contact us if you would like re-prints of any of these articles.
Arvidson, K. B. FDA toxicity databases and real-time data entry,Toxicol Appl Pharmacol. 2008, Jul 2.
Fostel, J. M. Towards standards for data exchange and integration and their impact on a public database such as CEBS (Chemical Effects in Biological Systems),Toxicol Appl Pharmacol. 2008, Jul 2.
Blower, P. E.; Cross, K. P. Decision Tree Methods in Pharmaceutical Research, Curr Top Med Chem. 2006, 6(1):31-9.
Blower, P. E.; Cross, K. P.; Eichler, G. S.; Myatt, G. J.; Weinstein, J. N.; and Yang, C. Comparison of Methods for Sequential Screening of Large Compound Sets, Comb Chem High Throughput Screen. 2006, 9(2):115-22.
Yang, C.; Benz, R. D.; Cheeseman, M. A. Landscape of current toxicity databases and database standards, Curr Opin Drug Discov Devel 2006, 9(1):124-33.
Huang, R.; Wallqvist, A.; Covell, D. G. Assessment of in Vitro and in Vivo Activities in the National Cancer Institute's Anticancer Screen with Respect to Chemical Structure, Target Specificity, and Mechanism of Action. J. Med. Chem. 2006, 49(6); 1964-1979.
Huang, Y.; Blower, P. E.; Yang, C.; Barbacioru, C.; Dai, Z.; Zhang, Y.; Xiao, J. J.; Chan, K. K.; and Sade, W. Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1 (ABCB1), Pharmacogen. J. 2005, 5(2):112-25.
Yang, C.; Cross, K.; Myatt, G.; Blower, P.; Rathman, J. Building Predictive Models For PTP1B Inhibitors Based On Discriminating Structural Features By Reassembling Medicinal Chemistry Building Blocks, J. Med. Chem., 2004, 47, 5984-5994.
Myatt, G.J.; Zhengming, C.; Yang, C.; Cross, K.; Blower, P. Data Mining and Visualization in Drug Discovery, AAPS Newsletter, September 2004, 16-19.
Blower, P.; Cross, K.; Fligner, M.; Myatt, G.; Verducci, J.; and Yang, C. Systematic analysis of large screening sets, Curr. Drug Disc. Technol., 2004, 37-47.
Cross, K.P.; Myatt, G.; Yang, C.; Fligner, M.F.;Verducci, J.S.; Blower, Jr., P.E. Finding Discriminating Structural Features by Reassembling Common Building Blocks, J. Med. Chem., 2003, 46, 4770-4775.
Blower, P. E. Jr.; Yang, C; Fligner, M. A.; Verducci, J. S.; Yu, L.; Richman, S.; Weinstein, J. N. Pharmacogenomic Analysis: Correlating Molecular Substructure Classes with Microarray Gene Expression Data, Pharmacogen. J. 2002, 2, 259-271.
Fligner, M. A.; Verducci, J. S.; Blower, P. E. Jr. A Modification of the Jaccard/Tanimoto Similarity Index for Diverse Selection of Chemical Compounds Using Binary Strings, Technometrics, 2002, 44, 110-19.
P. Blower, M. Fligner, J. Verducci, and J. Bjoraker; On Combining Recursive Partitioning and Simulated Annealing To Detect Groups of Biologically Active Compounds, J. Chem. Inf. Comput. Sci., 2002, 42, 393-404.
Yang, C.; Bakshi, B.R.; Rathman, J.F.; and Blower Jr., P. E. Multiscale and Bayesian approaches to data analysis in genomics highthroughput screening, Curr. Opin. Drug Disc. Devel. 2002, 5
Johnson, D. E.; Blower, P. E., Jr.; Myatt, G. J.; Wolfgang, G. H. I. Chem-tox informatics: data mining using a medicinal chemistry building block approach, Curr. Opin. Drug Discovery Dev. 2001, 4, 92-101.
Richon, A.; LeadScope: data visualization for large volumes of chemical and biological screening data, J Mol Graph Model. 2000, 18(1):76-9.
Roberts, G.; Myatt, G. J.; Johnson, W. P.; Cross, K. P.; Blower, P. E. Jr. LeadScope: Software for Exploring Large Sets of Screening Data, J. Chem. Inf. Comput. Sci. 2000, 40, 1302-1314.
