Non-human Developmental Toxicity Suite*

Non-human Developmental Toxicity Suite*
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The Leadscope Model Applier
    The models in the Developmental Toxicity Suite intend to support regulatory decision-making processes. The Leadscope QSAR models of developmental toxicity of the rodent fetus include dysmorphogenesis (structural and visceral birth defects), developmental toxicity (fetal growth retardation and weight decrease), and fetal survival (fetal death, post-implantation loss, and preimplantation loss).
    This suite includes the following Model Endpoints:
    Model EndpointRodent CompositeRatMouseRabbit
    Structural dysmorphogenesisyesyesyesyes
    Visceral dysmorphogenesisyesyesyes
    Fetal growth retardationyesyesyesyes
    Fetal weight decreaseyesyesyesyes
    Fetal survival: fetal deathyesyesyesyes
    Fetal survival: post-implantation lossyesyesyesyes
    Fetal survival: pre-implantation lossyesyesyesyes

    • Applicability domain defined by nearest neighbor analysis - explicit comparison of structural feature representations and coverage of test sets vs. the model
  • Stand-alone product with read-only models
  • Test structures entered in SMILES or MOL/SDF formats
  • Batch predictions
    Windows XP or Vista with at least a Pentium 4, 1.0GHz processor (or equivalent) with Minimum 1.0 GB of RAM and 1 GB of disk space

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