Drugs Chronic/Subchronic Database**

Drugs Chronic/Subchronic Database**

Specialized Chronic/Sub-chronic Database

Description

The Leadscope Drugs Chronic/Sub-chronic Database is a comprehensive, high quality chronic and subchronic toxicity database from the US FDA CDER (Center for Drug Evaluation and Research) product approval reviews. Includes 121 drugs and drug products filed in New Drug Application (NDA) reviews containing studies for 1 year, 6 months and 3 months.

Features

  • Test system includes rats, mice, dogs, and monkeys with mostly oral and inhalation exposures (587 tests).
  • The compounds are stratified across carcinogenic and genotoxic potentials: ~ 50% non-genotoxic carcinogens.
  • Toxicity information extracted from pharmacological reviews in NDA and include the following results:
    • clinical signs
    • clinical chemistry
    • hematology
    • histopathology
    • urinalysis
  • Access to the raw data in SD and XML file formats, using the public ToxML controlled vocabulary.

Requirements

Leadscope Enterprise, Leadscope Hosted or Leadscope Personal

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