Non-human Genetic Toxicity Suite*

Non-human Genetic Toxicity Suite*

The Non-human Genetic Toxicity Model Suite includes predictive (Q)SAR models to evaluate the potential genotoxicity of test chemicals.

Description

Selected Models
  • Salmonella Mutagenicity
  • E. coli Mutagenicity
  • Mouse Lymphoma
  • In Vitro Chromosome Aberrations
  • In Vivo Micronucleus

Applicability Domain
Applicability domain defined by nearest neighbor analysis - explicit comparison of structural feature representations and coverage of test sets vs. the model FDA/CDER/Division of Drug Safety Research publications document the weight of evidence methods and data sources employed.

Leadscope Model Applier Application Features

  • Stand-alone product with read-only models
  • Test structures entered in SMILES or MOL/SDF formats
  • Batch predictions

Requirements

  • Windows XP, Vista, 7, or 8 with a minimum 1.0GHz processor, a minimum of 1.0 GB of available memory, and a minimum of 10 GB of available disk space

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