Toxicity Consulting Program
Leadscope partners with several leading Toxicology Consultants. Should you need additional expertise choose one of the partners listed below. They have access to and are trained in the use of the Leadscope software, Toxicity Databases and QSAR Toxicity Prediction Suites.
Toxicology Knowledge Team Sweden AB
SE 151 85 Södertälje
Tel: +46-(0)8-553 251 24 alt. +46-(0)8-553 251 25
The founding principle of Toxicology Knowledge Team's business strategy is to offer each client access to all of our combined expertise and problem solving abilities, in a tailor made fashion. Our staff have extensive experience in safety assessment of potential drug targets, an important component of early stage drug discovery projects. We also support companies that have more advanced pharmaceutical projects with design, monitoring and review of outsourced toxicology studies, as well as the generation of regulatory documentation.
Our in silico toxicity prediction services combine expert judgment with predictions from both proprietary models (Leadscope, DEREK) as well as publicly available software (e.g. the OECD QSAR Toolbox and CAESAR).
With headquarters in the greater Philadelphia area, PharmaFacts functions very much in a 21st century virtual mode, bringing together over 30 industry experts from all over the world, on an as needed basis, to partner with you in the facilitation and conduct of your entire Drug Discovery/Development Program. PharmaFacts specializes in partnering and facilitating the conduct of all aspects of preclinical drug development and IND-enabling studies, from Discovery to the Monitoring of Preclinical Trials to the Report Generation and Development Team Activities to the Management behind it all. Companies can then meet their schedules and workloads, take advantage of the latest technologies, adhere to GLP and regulatory guidelines and successfully meet your milestones.
Lisa D. Beilke, MSPH, PhD, DABT
San Diego, CA 92126
Toxicology Solutions is an independent consulting company focused on providing small molecule toxicology services to the pharmaceutical industry. Specialty services include in silico toxicity predictions using 3 major predictive software programs (Leadscope Model Applier, DEREK Nexus, and MultiCase).
Computational Toxicology Services offers a cost effective solution for pharmaceutical and chemical industry clients with toxicity screening needs that do not justify the investment in QSAR software, database modules and staff required to carry out independent computational toxicology screening. SciQSAR (MDL-QSAR), LeadScope and Derek predictive modules are available for the major toxicology studies necessary for the marketing of pharmaceuticals and food contact substances in the US and internationally and are currently being used as decision support tools for safety assessment by the FDA (1-5). The Computational Toxicology Services modules contain information derived from public sources and available under the freedom of information act.
Toxicology Consulting is an evaluation and communication process employed to convert technical toxicological data into useable knowledge which is then applied in the management of chemical risks.
Hilary V. Sheevers, Ph.D.
Regulatory Toxicologist, President & CEO
Aclairo Pharmaceutical Development Group, Inc.
1950 Old Gallows Road, Suite 300
Vienna, VA 22182
Telephone: +1 703-506-6760 ext 307
Our mission is to make clear the proper path for development of drug products; and to help implement this path with superior scientific and regulatory advice.
exeResearch is an independent research company providing computational chemistry and biochemistry research assistance to those in academia and industry. We help scientists without the resources, time, or knowledge to complete the needed computational aspects of their research projects.
Raymond A. Cardona, Ph.D., DABT
ChemTox Consulting, LLC
34 Pilgrim Lane
Naugatuck, CT 06770
CTC is an independent consulting company specializing in domestic and global issues in the areas of pesticide toxicology, risk assessment, product registration and regulatory affaris. Computational models, such as Leadscope, and expert opinion, are provided to expedite discovery and new product development programs. In silico environmental fate and aquatic toxicity modeling is also available. Prediction of a compounds potential toxicity and evironmental fate facilitates lead candidate product optimization and selection.
Prof. Dr. Klaus Kümmerer, CEOO
Martin Luther Straße 1
Telephone: +49 (0) 7644 / 32 87 84 9
Mobile: +49 (0) 162 / 27 36 46 7
EDC is an experienced and competent partner for the evaluation of existing chemicals and the targeted design, improvement, and optimization of chemicals and active pharmaceutical ingredients. For this purpose we use computer-based methods for the calculation of substance properties, targeted research and experimental expertise.
Ronald D. Snyder, Ph.D
Telephone: (973) 347 3075
Specializing in Genetic Toxicology evaluation and issue resolution based on more than 25 years in industry leadership roles with responsibilities for Discovery and regulatory Genetic Toxicology programs. Particular strengths include mechanism-based genotoxicity assessment and in silico analysis using Leadscope, DEREK and VITIC.
We also offer manuscript copyediting prior to or after journal submission. This service provides a grammatically-correct document as well as, if requested, a high level assessment of the Science; are all the data there to substantiate the conclusions drawn by the authors.
Dr David Woolley
PO Box 13550, Linlithgow, EH49 7YU
Tel: +44(0) 1506 844036
ForthTox is an independent, toxicological consultancy working in pharmaceutical and chemical development; we are located in Scotland. We offer two proprietary in silico models for prediction of toxicity: Leadscope and Derek Nexus and use other software, such as T.E.S.T., CAESAR and ToxTree as appropriate; we also have a licence for METEOR for prediction of metabolism, allowing cross-checking of metabolites for toxicity. The results of in silico evaluation are validated, where appropriate, by reference to reports for closely related substances or by read across to groups of related chemicals, depending on context and information availability. We have extensive experience with in silico and in cerebro evaluations and our reports have been submitted to, and accepted by, major authorities including FDA and EMA.