2010 Drugs Chronic/Subchronic Database**

2010 Drugs Chronic/Subchronic Database**
$250
One-year license

Rapidly access chemical and chronic/subchronic toxicity data

Easily identify similar chemical substances


Use the Leadscope Database Viewer to search the database based on name


Explore in-depth chronic and sub-chronic data for compounds of interest
  • Comprehensive high quality chronic-subchronic toxicity database.
** developed under a CRADA with U.S. FDA - CDER
  • Includes 121 drugs and drug products filed in New Drug Application (NDA) reviews containing studies for 1 year, 6 months and 3 months.
  • Test system includes rats, mice, dogs, and monkeys with mostly oral and inhalation exposures (587 tests).
  • The compounds are stratified across carcinogenic and genotoxic potentials: ~ 50% non-genotoxic carcinogens.
  • Toxicity information extracted from pharmacological reviews in NDA and include the following results:
    • clinical signs
    • clinical chemistry
    • hematology
    • histopathology
    • urinalysis …
  • Access to the raw data in SD and XML file formats, using the public ToxML controlled vocabulary.
  • A database viewer is provided with the data and requires Windows 2000 or XP with at least a PIII 700MHz processor (or equivalent) with 256MB of RAM and 500MB of disk space

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