2010 Drugs Repro-Developmental Database**

2010 Drugs Repro-Developmental Database**
$250
One-year license

Locate Reproductive-Developmental toxicity findings for drug-like chemicals


Use the Leadscope Database Viewer to search the database based on chemical feature


Explore in-depth chronic and sub-chronic data for compounds of interest
  • Comprehensive high quality database containing reproductive and developmental studies
**Produced under a CRADA with FDA Center for Drug Evaluation and Research (CDER)
  • Includes 58 drugs and drug products filed in New Drug application (NDA) reviews.
  • Test system includes mostly rats and studies include mostly Segment II (Developmental) studies.
  • The compounds are stratified across carcinogenic and genotoxic potentials.
  • Studies include:
    • Maternal toxicity
    • Offspring toxicity
      • survival
      • growth
      • morphology
  • Access to the raw data in SD and XML file formats, using the public ToxML controlled vocabulary.
  • A database viewer is provided with the data and requires Windows 2000 or XP with at least a PIII 700MHz processor (or equivalent) with 256MB of RAM and 500MB of disk space.

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