Human Adverse Hepatobiliary Effects Suite*

Human Adverse Hepatobiliary Effects Suite*

Models to support decision-making processes on hepatobiliary effects of pharmaceutical like chemicals.


The endpoints covered by this suite of models include:
  • Bile duct disorders
  • Gall bladder disorders
  • Liver jaundice disorders
  • Liver acute damage disorders
  • Liver enzyme release disorders
Applicability domain defined by nearest neighbor analysis - explicit comparison of structural feature representations and coverage of test sets vs. the model

Leadscope Model Applier Software Features

  • Stand-alone product with read-only models
  • Test structures entered in SMILES or MOL/SDF formats
  • Batch predictions


  • Windows XP, Vista, 7, or 8 with a minimum 1.0GHz processor, a minimum of 1.0 GB of available memory, and a minimum of 10 GB of available disk space