Statistical models designed to support developmental toxicity prioritization in the regulatory decision-making process.

Description

The Developmental Toxicity Statistical Model Suite includes the following endpoints:

Model Endpoint	Rodent Composite	Rat	Mouse	Rabbit
Structural dysmorphogenesis
Visceral dysmorphogenesis
Fetal growth retardation
Fetal weight decrease
Fetal survival: fetal death
Fetal survival: post-implantation loss
Fetal survival: pre-implantation loss

Applicability domain defined by nearest neighbor analysis - explicit comparison of structural feature representations and coverage of test sets vs. the model

Leadscope Model Applier Software Features

• Stand-alone product with read-only models
• Test structures entered in SMILES or MOL/SDF formats
• Batch predictions

Requirements

• Windows XP, Vista, 7, or 8 with a minimum 1.0GHz processor, a minimum of 1.0 GB of available memory, and a minimum of 10 GB of available disk space